Полина Лосева - Против часовой стрелки

• Название: Против часовой стрелки
• Автор: Полина Лосева
• Жанр: Биология
• Год: 2020
• ISBN: 978-5-0013-9314-6

Ученые ищут лекарство от старости уже не первую сотню лет, но до сих пор, кажется, ничего не нашли. Значит ли это, что его не существует? Или, может быть, они просто не там ищут? В своей книге биолог и научный журналист Полина Лосева выступает в роли адвоката современной науки о старении и рассказывает о том, чем сегодня занимаются геронтологи и как правильно интерпретировать полученные ими результаты. Кто виноват в том, что мы стареем? Что может стать нашей защитой от старости: теломераза или антиоксиданты, гормоны или диеты? Биологи пока не пришли к единому ответу на эти вопросы, и читателю, если он решится перейти от размышлений к действиям, предстоит сделать собственный выбор. Эта книга станет путеводителем по современным теориям старения не только для биологов, но и для всех, кому интересно, как помочь своему телу вести неравную борьбу со временем.

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4

Bae T. et al. Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis // Science. 2018 Feb; 359 (6375): 550–555.

5

Lodato M. A. et al. Aging and neurodegeneration are associated with increased mutations in single human neurons // Science. 2018 Feb; 359 (6375): 555–559.

6

Blokzijl F. et al. Tissue-specific mutation accumulation in human adult stem cells during life // Nature. 2016 Oct; 538: 260–264.

7

Федеральная служба государственной статистики. Статистический бюллетень 2007 года.

8

Международная классификация болезней 10-го пересмотра (МКБ-10). Mkb-10.com

9

Bulterijs S., Hull R., Björk V., Roy A. It is time to classify biological aging as a disease // Frontiers in genetics. 2015 Jun.

10

Gompertz B. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies // Philosophical transactions of the Royal Society. 1825: 513–528.

11

Makeham W. M. On the law of mortality // Journal of the Institue of Actuaries. 1867 Jul; 13 (6): 325–358.

12

Golubev A. How could the Gompertz-Makeham law evolve // Joournal of Theoretical Biology. 2009 May; 258 (1):1–17.

13

Dickinson M. E. et al. High-throughput discovery of novel developmental phenotypes // Nature. 2016 Sep; 537: 508–514.

14

Kinzina E. D., Podolskiy D. I., Dmitriev S. E., Gladyshev V. N. Patterns of aging biomarkers, mortality, and damaging mutations illuminate the beginning of aging and causes of early-life mortality // Cell Reports. 2019 Dec; 29 (13): 4276–4284.

15

Olshansky S. J. On the biodemography of aging: a review essay // Population and development review. 1998 Jun; 24 (2): 381–393.

16

Barbi E., Lagona F., Marsili M., Vaupel J. W., Wachter K. W. The plateau of human mortality: Demography of longevity pioneers // Science. 2018 Jun; 360 (6396): 1459–1461.

17

Gavrilov L. A., Gavrilova N. S. Mortality measurement at advanced ages // North American Actuarial Journal. 2012 Dec; 15 (3): 432–447.

18

Newman S. J. Errors as a primary cause of late-life mortality deceleration and plateaus // PLOS Biology. 2018 Dec 16 (12): e2006776.

19

Gavrilov L. A., Gavrilova N. S. New trend in old-age mortality: gompertzialization of mortality trajectory // Gerontology. 2019; 65 (5): 451–457.

20

Yang Y., Santos A. L., Xu L. Lotton C., Taddei F., Lindner A. B. Temporal scaling of aging as an adaptive strategy of Escherichia coli // Science Advances. 2019 May; 5 (5): eaaw2069.

21

Голубев А. Г. Проблемы обсуждения вопроса о возможности подходов к построению общей теории старения. I. Обобщенный закон Гомпертца – Мэйкхема // Успехи геронтологии. 2009; 22 (1). С. 60–74.

22

Liu X. Life equations for the senescence process // Biochemistry and Biophyscis Reports. 2015 Dec; 4: 228–233.

23

Anisimov V. N. Carcinogenesis and aging // Advances in Cancer Research. 1983; 40: 365–424.

24

Gems D. The aging-disease false dichotomy: understanding senescence as pathology // Frontiers in Genetics. 2015 Jun.

25

Müthel S. et al. The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans // Aging Cell. 2019 Aug; 18 (6): e13012.

26

https://www.who.int/gho/mortality_burden_disease/life_tables/situation_trends/en ./

27

Roser M. Life Expectancy, 2016. Опубликовано на OurWorldInData.org. Цит. по: http://ourworldindata.org/data/population-growth-vital-statistics/life-expectancy /

28

https://www.who.int/gho/mortality_burden_disease/life_tables/situation_trends_text/en ./

29

https://www.who.int/gho/women_and_health/mortality/situation_trends_life_expectancy/en ./

30

Preston S. H. The changing relation between mortality and level of economic development // Population Studies. 1975; 29 (2): 231–248.

31

Shkolnikov V. M., Andreev E. M., Tursun-Zade R., Leon D. A. Patterns in the relationship between life expectancy and gross domestic product in Russia in 2005–15: a cross-sectional analysis // The Lancet Public Health. 2019 Apr; 4 (4): E181–E188.

32

Angel J. L. The bases of paleodemography // American Journal of Physical Anthropology. 1969 May; 30 (3): 427–437.

33

Kaplan H., Hill K., Lancaster J., Hurtado M. A. A theory of human life history evolution: Diet, intelligence, and longevity // Evolutionary Anthropology: Issues, News, and Reviews.. 2000 Aug; 9 (4): 156–185.

34

Marlowe F. The Hadza. In: Ember C. R., Ember M. (eds) Encyclopedia of Medical Anthropology. Springer, 2004.

35

Gurven M., Kaplan H. Longevity among hunters-gatherers: a cross-cultural examination // Population and Development Review. 2007 May; 33 (2): 321–365.

36

Lancaster H. O. Expectations of Life: A Study in the Demography, Statistics, and History of World Mortality. Springer Science & Business Media, 1990.

37

The Human Mortality Database, www.mortality.org.. Цит. по: https://web.archive.org/web/20160406131456/ http:/www.mortality.org ./

38

См. п. 26.

39

Oeppen J., Vaupel J. W. Broken limits to life expectancy // Science. 2002 May; 296 (5570): 1029–1031.

40

Dong X., Milholland B., Vijg J. Evidence for a limit to human lifespan // Nature. 2016 Oct; 538: 257–259.

41

Hughes B. G., Hekimi S. Many possible maximum lifespan trajectories // Nature. 2017 Jun; 546: E8–E9.

42

Zak N. Jeanne Calment: the secret of longevity // Research Gate. 2018 Dec; 10.13140/RG.2.2.29345.04964.

43

Maier H., Gampe J., Jeune B., Vaupel J. W., Robine J.-M. Supercentenarians. Springer Science & Business Media, 2010.

44

McMurray S. E., Blum J. E., Pawlik J. R. Redwood of the reef: growth and age of the giant barrel sponge Xestospongia muta in the Florida Keys // Marine Biology. 2008 Jun; 155: 159–171.

45

Jochum K. P., Wang X., Vennemann T. W., Sinha B., Müller W. E. G. Siliceous deep-sea sponge Monorhaphis chuni: A potential paleoclimate archive in ancient animals // Chemical Geology. 2012 Mar; 300–301: 143–151.

46

Roark E. B., Guilderson T. P., Dunbar R. B., Fallon S. J., Mucciarone D. A. Extreme longevity in proteinaceous deep-sea corals // PNAS. 2009 Mar; 106 (13): 5204–5208.

47

Butler P. G. et al. Variability of marine climate on the North Icelandic Shelf in a 1357-year proxy archive based on growth increments in the bivalve Arctica islandica // Palaeogeography, Palaeoclimatology, Palaeoecology.. 2013 Mar; 373 (1): 141–151.

48

Nielsen J. et al. Eye lens radiocarbon reveals centuries of longevity in the Greenland shark (Somniosus microcephalus) // Science. 2016 Aug; 353 (6300): 702–704.

49

Helama S. & Valovirta I. The oldest recorded animal in Finland: ontogenetic age and growth in Margaritifera margaritifera (L. 1758) based on internal shell increments // Memoranda Soc. Fauna Flora Fennica. 2008; 84:20–30.

50

Ebert T. A. Red sea urchins (Strongylocentrotus franciscanus) can live over 100 years: confirmation with A-bomb 14carbon // Fischery Bulletin. 2003; 101 (4): 915–922.

51

Cailliet G. M. et al. Age determination and validation studies of marine fishes: do deep-dwellers live longer? // Experimental Gerontology. 2001 Apr; 36 (4–6): 739–764.

52

Petralia R. S., Mattson M. P., Yao P. J. Aging and longevity in the simplest animals and the quest for immortality // Ageing Research Reviews. 2014 Jul; 16: 66–82.

53

George J. C. et al. Age and growth estimates of bowhead whales (Balaena mysticetus) via aspartic acid racemization // Canadian Journal of Zoology. 1999; 77 (4): 571–580.

54

Jones et al. Diversity of ageing across the tree of life // Nature. 2013 Dec; 505: 169–173.

55

Martínez D. E. Mortality Patterns Suggest Lack of Senescence in Hydra // Experimental Gerontology. 1998 Mar; 33 (3): 217–225.

56

Schaible R., Ringelhan F., Kramer B., Miethe T. Environmental challenges improve resource utilization for asexual reproduction and maintenance in hydra // Experimental Gerontology. 2011 Oct; 46 (10): 794–802.

57

Cм. п. 53.